New biologically active fluorescent cyclic nucleotides

Details New biologically active fluorescent cyclic nucleotides New biologically active fluorescent cyclic nucleotides

1986-05-23

1989-01-10

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07H 1910, C07H 1920

Patent

active

047974800

ABSTRACT:
Sybthesis of new biologically active fluorescent cyclic nucleotides of general formula: ##STR1## wherein X=OH and Y=NH.sub.2 or X=NH.sub.2 and Y=H and L is a fluorescent group of the class of 5 (or 6)-thioacetamido-fluorescein or of 5(or 8)-(2 thioacetamido-ethyl)-amino-naphthalene -1-sulphonic acid.

REFERENCES:
patent: 3712885 (1973-01-01), Weimann et al.
patent: 3988442 (1976-10-01), Cehouic
patent: 4369181 (1983-01-01), Miller et al.
Miller et al., Am. Chem. Soc., (1973) 12, 5310.
Antonio Caretta et al., "Binding Stoichiometry of a Fluorescent cGMP Analogue to Membranes of Retinal Rod Outer Segments", 1985, Eur. J. Biochem., 153(1), pp. 49-53.

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