Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-09-04
1997-11-25
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514183, 514200, 514212, 5142315, 5142338, 5142345, 5142352, 5142355, 5142358, 5142368, 5142372, 514252, 514256, 514258, 514266, 514321, 514422, 514423, 540354, 540480, 540483, 540544, 540553, 540597, 540600, 540603, 544124, 544127, 544128, 544129, 544130, 544133, 544135, 544137, 544139, 544141, 544238, 544242, 544277, 544283, 544336, 546208, 546209, 546210, 546211, 546212, 546214, 548517, 548548, 548572, A61K 31445, A61K 3140, A61K 31495, A61K 31535, A61K 3154, C07D40112, C07D20709, C07D21128
Patent
active
056913567
ABSTRACT:
Disubstituted heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein G is ##STR2## wherein n is 0, 1 or 2 or 3; m is 0, 1, 2 or 3; Y is NH or S; p is 0, 1 or 2, Q is a single bond or ##STR3## and Z, A, R, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.6 are as defined herein.
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Robert M. Knabb et al, "In Vivo Characterization of a New Synthetic Thrombin Inhibitor," Thrombosis and Hemostasis (1992) 67, 56-59.
Charles V. Jackson et al, "Pharmacological Assessment of the Antithrombotic Activity of the Peptide Thrombin Inhibitor, D-Methyl-Phenylalanyl-Prolyl-Arginal (GYKI-14766), in Canine Model of Coronary Artery Thrombosis," J. Pharm. Exp. Ther. (1992) 261, 546-552.
Das Jagabandhu
Kimball Spencer D.
Lau Wan Fang
Bristol--Myers Squibb Company
Huang Evelyn
Ivy C. Warren
Rodney Burton
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