Cyclodextrin cellular delivery system for oligonucleotides

Details Cyclodextrin cellular delivery system for oligonucleotides Cyclodextrin cellular delivery system for oligonucleotides

1994-11-17

1997-11-25

Campell, Bruce R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 231, 536 245, 536103, 424488, A61K 4800, C07H 2102, C07H 2104, C08B 3716

Patent

active

056913168

ABSTRACT:
Disclosed is a composition including an oligonucleotide complexed with a cyclodextrin. The oligonucleotide may be noncovalently associated with the cyclodextrin. Alternatively, the oligonucleotide may be covalently complexed with adamantane which is noncovalently associated with the cyclodextrin. Also disclosed are methods of enhancing the cellular uptake and intracellular concentration of oligonucleotides, methods of increasing the solubility of an oligonucleotide in a cell, and methods of treating a cell for viral infection or to prevent viral infection.

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