Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1994-11-15
1997-11-25
Wax, Robert A.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
435198, 4353201, 4352523, 4352402, 536 232, 536 234, C12N 920, C12N 1555, C12N 1585
Patent
active
056911815
ABSTRACT:
A human gastric lipase protein for use in the treatment of lipase deficiency. A process is described for producing gastric lipase using recombinant DNA technology to produce a host organism (for example E. coli) capable of producing a methionine-gastric lipase or precursor of the gastric lipase which may be cleaved to yield the gastric lipase. The host organism is transformed with a vector including a gene coding for a methionine-gastric lipase or a precursor of gastric lipase. The precursor protein is for example, pregastric lipase protein, or a fusion protein comprising gastric lipase and a heterologous protein. A pharmaceutical composition in unit dosage or liquid form is described.
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Celltech Limited
Hendricks Keith D.
Wax Robert A.
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