Ornithine and arginine salts of branched chain keto acids and us

Details Ornithine and arginine salts of branched chain keto acids and us Ornithine and arginine salts of branched chain keto acids and us

1978-03-17

1980-10-14

Robinson, Allen J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424311, 424319, C07C10100, C07C10102

Patent

active

042280990

ABSTRACT:
Novel compounds are prepared by reacting ornithine or arginine with alpha keto analogs of branched chain essential amino acids, namely valine, leucine and isoleucine. The compounds are useful either individually or as a mixture in the treatment of hepatic disorders which are characterized by hyperammonemia and portal systemic encephalopathy. Use of these compounds in treatment of renal failure also appears promising.

REFERENCES:
patent: 3441650 (1969-04-01), Georges
patent: 3950529 (1976-04-01), Fischer et al.
patent: 4100293 (1978-07-01), Walser
Matsuzawa; J. Biochemistry, 75:601-609 (1974).
Chainuvati et al.; Acta Hepato-Gastroenterol, 24(1977) 434-439.
Rognstad; Biochimica et Biophysica Acta 496, 249-254 (1977).
Kisfaludy; Mat. Med. Nordm. 29(1977) pp. 315-325.
Molimard et al; III. Internationales Ammonich Symposium (1977) pp. 200-206.
Muting et al.; Munchener Medizinische Wochenschrift, 1977, pp. 1-12.

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