Use of N-(substituted glycyl)-2-cyanopyrrolidines in inhibiting

Details Use of N-(substituted glycyl)-2-cyanopyrrolidines in inhibiting Use of N-(substituted glycyl)-2-cyanopyrrolidines in inhibiting

1999-10-20

2000-09-26

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514343, 514406, 514412, 514423, 514333, A61K 31505, A61K 3144, A61K 31415, A61K 3140

Patent

active

061243051

ABSTRACT:
N-(N'-substituted glycyl)-2-cyanopyrrolidines of formula I ##STR1## wherein R is as defined herein. Compounds of formula I inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore indicated for use as pharmaceuticals in inhibiting DPP-IV and in the treatment of conditions mediated by DPP-IV, such as non-insulin-dependent diabetes mellitus, arthritis, obesity, osteoporosis and further conditions of impaired glucose tolerance.

REFERENCES:
patent: 4229465 (1980-10-01), Ohkuma et al.
patent: 4849435 (1989-07-01), Wallweber et al.
patent: 4923883 (1990-05-01), Wallweber et al.
patent: 4977182 (1990-12-01), Wallweber et al.
Li et al., Archives of Biochemistry and Biophysics, vol. 323, No. 1, pp. 148-154 (1995).
Li et al., Journal of Neurochemistry, vol. 66, pp. 2105-2112 (1996).
Yamada et al., Bulletin of the Chemical Society of Japan, vol. 50, No. 7, pp. 1827-1830 (1977).
Yamada et al., Bulletin of the Chemical Society of Japan, vol. 51, No. 3, pp. 878-833 (1978).
Derwent Abstract 95-302548.
Derwent Abstract 84-177689.
Derwent Abstract 96-116353.
Kaspari et al., Biochimica et Biophysica, vol. 1293, pp. 147-153.
Ashworth et al., Bioorganic and Medicinal Chemistry Letters, vol. 6, No. 10, pp. 1163-1166 (1996).
Coutts et al., J. Med. Chem., vol. 39, pp. 2087-2094 (1996).
Deacon et al., Diabetes, vol. 44, pp. 126-1131 (Sep. '96).
Ashworth et al., Bioorganic and Medicinal Chemistry Letters, vol. 6, No. 22, pp. 2745-2748 (1996).
Augustyns et al., Eur. J. Med. Chem., vol. 32, pp. 301-309 (1997).

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