Methods for the use of spermidine/spermine N.sup.1 -acetyltransf

Details Methods for the use of spermidine/spermine N.sup.1 -acetyltransf Methods for the use of spermidine/spermine N.sup.1 -acetyltransf

1993-11-16

1996-03-12

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 71, 435 74, 435 15, 435 911, 435 912, 435810, 435 29, 5303871, 536 221, 514674, A61K 4900, C12Q 102, C12Q 148, C12Q 168, G01N 33573

Patent

active

054985226

ABSTRACT:
Disclosed is a method that relates to the measurement of determinants related to the in-vivo induction of spermidine/spermine N.sup.1 -acetyltransferase (SSAT), subsequent to polyamine analog treatment (such as with a bis-ethyl spermine analog) of human malignant solid tumor types responsive to the polyamine analog. The method comprises the measurement of one or more SSAT-specific determinants that include SSAT enzyme activity, SSAT enzyme protein, and SSAT m-RNA transcripts. Alternatively, other determinants related to the SSAT induction may be measured. Such determinants include SSAT co-factor acetylCoenzyme A, and SSAT products N.sup.1 -acetylspermidine and N.sup.1 -acetylspermine. Measurements of these determinants may be useful as prognostic indicia and tumor response markers to evaluate the clinical effectiveness of anticancer agents comprising polyamine analogs.

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