Tricyclic thromboxane A.sub.2 antagonists

Details Tricyclic thromboxane A.sub.2 antagonists Tricyclic thromboxane A.sub.2 antagonists

1992-05-18

1994-04-12

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 514424, 514428, 540604, 540609, 540610, 546203, 546204, 548525, A61K 31445, C07D21122

Patent

active

053026020

ABSTRACT:
Novel tricyclic compounds having a TXA.sub.2 antagonizing activity represented by formula (I): ##STR1## possess a potent antagonizing against thromboxane A.sub.2 and also an antiallergic and/or antihistaminic activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.

REFERENCES:
patent: 3354155 (1967-11-01), Tretter
patent: 3420851 (1969-01-01), Bloom et al.
patent: 4282365 (1981-08-01), Rokach et al.
patent: 4585788 (1986-04-01), Helsley et al.
patent: 4596809 (1986-06-01), Takizawa et al.
patent: 4749703 (1988-06-01), Uso et al.
patent: 4912222 (1990-03-01), Griffith et al.
Arz.--Forsch., 13, 1039 (1963).
Arz.-Forsch., 14, 100 (1964).
J. Med. Chem. 21, 633 (1978).
Chem. Abstracts, vol. 72, 308 (1970) No. 3387d.
Chem. Abstracts, vol. 81, 424 (1974), No. 25566z.
Eur. J. Med. Chem.-Chimica Therapeutica, P. Dostert et al., "Composes Tricycliques portant une chaine alkylaminoalkylthio. Synthese et activite pharmacologique," May-Jun. 1974-9, No. 3, p. 259.
J. Med. Chem., M. Cerelli et al., "Antiinflammatory and Aldose Reductase Inhibitory Activity of Some Tricyclic Arylacetic Acids," vol. 29, 2347 (1986).

Affiliated with

Also associated with

Rating

Tricyclic thromboxane A.sub.2 antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tricyclic thromboxane A.sub.2 antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tricyclic thromboxane A.sub.2 antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2098898