Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1998-04-21
2000-09-26
Horlick, Kenneth R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
536 221, 536 231, 536 243, 536 2431, 536 2432, 536 2433, 435 5, 435 6, 345 1, 345 47, 345185, G01N 3353, C07H 2104, C07H 1900, G09G 500, G09G 306
Patent
active
061241024
ABSTRACT:
The invention provides a method for analyzing the binding between a receptor and ligand using a probe array. The method generally involves contacting a labeled receptor with a substrate that includes a plurality of known locations to permit labeled receptor/ligand complexes to form. Intensity values based upon signal generated from bound labeled receptor are determined for a plurality of pixels within each of the known locations. A subset of pixels within each known location that fall within a statistical norm of intensity values for all the pixels within the known location is identified using a computer and then utilized to determine relative binding.
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Fodor Stephen P. A.
Holmes Christopher P.
Solas Dennis W.
Stryer Lubert
Winkler James L.
Affymetrix Inc.
Horlick Kenneth R.
Siew Jeffrey
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