Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-03-28
1991-02-12
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3136
Patent
active
049924672
ABSTRACT:
The compounds and pharmaceutical compositions of Formula A, wherein Z is hydrogen or --C(O)R, Y is hydrogen or morpholinoethyl, and where R is lower alkyl or aryl, and the pharmaceutically acceptable salts thereof, are useful as immunosuppressive agents, particularly for treatment of allograft rejection, especially including cardiac allograft rejection, pancreatic allograft rejection and renal allograft rejection, and for treating autoimmune diabetes. ##STR1##
REFERENCES:
patent: 3705894 (1972-06-01), Gerzon et al.
patent: 3777020 (1973-07-01), Johnson
patent: 3825571 (1974-04-01), Mori et al.
patent: 3853919 (1974-05-01), Mori et al.
patent: 3868454 (1975-05-01), Johnson
patent: 3880995 (1975-06-01), Jones
patent: 3903071 (1975-07-01), Holmes
"Antitumor Activity of Derivatives of Mycophenolic Acid", Suzuki, et al., J. Antibiotics, 29(3), 275-285, 1975.
"Carbamoyl Mycophenolic Acid Ethylester, An Oral Antitumor Agent", Suzuki, et al., J. Antibiotics, 29(3), 286-291, 1975.
"Antitumor and Immunosuppressive Effects of Mycophenolic Acid", Ohsugi, et al., Cancer Research, 36, 2923-2927, 1976.
"A Gastroprotective Anti-Inflammatory Agent: The .beta.-morpholinoethyl Ester of Niflumic Acid (Morniflumate)", Schiantarelli, et al., Agents and Actions, 14(2), 1984.
Allison Anthony C.
Eugui Elsie M.
Gu Chee-Liang L.
Lee William A.
Nelson Peter H.
Friedman Stanley J.
Lowin David A.
Moran Tom M.
Syntex (U.S.A.) Inc.
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