Method for removal of thiol-protecting groups

Details Method for removal of thiol-protecting groups Method for removal of thiol-protecting groups

1977-06-13

1978-09-05

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125S, 2601125T, C07C10352, C07G 700

Patent

active

041119240

ABSTRACT:
A novel method for removal of protective group(s) from an amino acid or peptide having thiol group(s) protected with p-methoxybenzyl, 1-adamantyl or t-butyl group by treating the protected amino acid or peptide with the mercuric salt of acetic acid or halogenoacetic acid, the removal being effected selectively and very smoothly in a good yield under extremely mild conditions without giving any undesirable influence upon other functional or protective group(s).

REFERENCES:
patent: 3560521 (1971-02-01), Milkowski et al.
patent: 3917578 (1975-11-01), Immer et al.

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