Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1989-04-17
1992-12-15
Kepplinger, Esther L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 79, 4351722, 43524027, 436548, 436813, 436 64, 5303877, 5303888, 53038885, G01N 33574, C12P 2108, C07K 1528
Patent
active
051716658
ABSTRACT:
The present invention is concerned with a novel monoclonal antibody which binds strongly to a protein antigen associated with human tumors, including carcinomas of the colon and lung. The antibody binds to normal human cells to a much lesser degree than to tumor cells. The antibody finds use both in diagnostic methods such as the detection of malignant cells associated with tumors and in therapeutic methods for treatment of humans with tumors. Also disclosed is a novel 66,000 dalton glycoprotein antigen found on the cell surface of human tumor cells. The amino terminal amino acid sequence of this antigen is: ##STR1## in which X represents an unidentified amino acid.
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Hellstrom Ingegerd
Hellstrom Karl E.
Marquardt Hans
Kepplinger Esther L.
Mandel SaraLynn
Oncogen
Scheiner Toni R.
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