Transient pro-drug forms of phenylbutazone

Details Transient pro-drug forms of phenylbutazone Transient pro-drug forms of phenylbutazone

1977-03-14

1978-09-26

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23134

Patent

active

041172329

ABSTRACT:
Novel, transient pro-drug forms of the anti-inflammatories phenylbutazone and oxyphenbutazone are disclosed, the same having the structural formulae: ##STR1## wherein R is a member selected from the group consisting of C.sub.1 -C.sub.2 alkylsulfonyl, phenylsulfonyl, p-tolylsulfonyl and naphthylsulfonyl, and ##STR2## wherein X and Y each represent a member selected from the group consisting of a hydrogen atom and ##STR3## with the proviso that either X or Y is a hydrogen atom, R.sub.1 is selected from the group consisting of C.sub.1 -C.sub.2 alkylsulfonyl, phenylsulfonyl, p-tolylsulfonyl and naphthylsulfonyl, and R.sub.2 is selected from the group consisting of straight or branched chain C.sub.1 -C.sub.5 alkyl and phenyl.

REFERENCES:
patent: 2905694 (1959-09-01), Pinson, Jr. et al.
patent: 3235542 (1966-02-01), Sarett et al.
patent: 3607881 (1968-06-01), Izquierdo
Gimbert, et al., Chem. Abs., vol. 77, 1972, 34511x.
Sala, et al., Chem. Abs., vol. 68, 1968, 95751m.

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