Method of making N-[4-chlorophenyl)amino]carbonyl)-2,6-difluorob

Details Method of making N-[4-chlorophenyl)amino]carbonyl)-2,6-difluorob Method of making N-[4-chlorophenyl)amino]carbonyl)-2,6-difluorob

1977-06-09

1978-09-26

Douglas, Winston A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C12722

Patent

active

041170091

ABSTRACT:
In accordance with the sought-after features of an improved process for the preparation of Dimilin, there is provided herein a process which comprises first extracting 2,6-difluorobenzamide from an aqueous acid solution with a selective solvent which is acid-stable and water-insoluble. The extract then is condensed in situ with p-chlorophenyl isocyanate at an elevated temperature to form the desired product. The selective solvent preferably has a boiling point at the reaction temperature, preferably about 120.degree.-170.degree. C. Finally, the product is crystallized from the selective solvent.

REFERENCES:
patent: 1633392 (1927-06-01), Boedecker
patent: 3627778 (1971-12-01), Nusslein et al.
patent: 4005223 (1977-01-01), Sirrenberg et al.
patent: 4013717 (1977-03-01), Wellings et al.
patent: 4068002 (1978-01-01), Sirrenberg et al.
Turner, J.A.C.S. 68, pp. 1607-1608 (1946).
Nickon et al., J.A.C.S. 74, 5566 (1952) - Abstract.

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