Method of inhibiting aromatase

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514255, 514256, 514320, 514340, 514377, 5142272, 5142288, A61K 3144, A61K 3154, A61K 31495, A61K 31505

Patent

active

047677708

ABSTRACT:
This invention provides a method of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals by administering certain amine derivatives. Pharmaceutical formulations of the compounds are also provided.

REFERENCES:
patent: 3681367 (1972-08-01), Lee
Carter et al., Chemotherapy of Cancer, 2nd ed, pp. 361, 364 and 365 (1981).
Lin et al., "The Synthesis of Substituted 2-Aminothiazoles", J. Het. Chem., 16, 377 (1979).

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