Novel derivatives of 2-(2-thienyl)-imidazo[4,5-b]-pyridines and

Details Novel derivatives of 2-(2-thienyl)-imidazo[4,5-b]-pyridines and Novel derivatives of 2-(2-thienyl)-imidazo[4,5-b]-pyridines and

1984-11-02

1986-06-24

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546118, A61K 3153, C07D49102

Patent

active

045968306

ABSTRACT:
The invention relates to new therapeutically valuable derivatives of 2-(2-thienyl)-imidazo[4,5-b]pyridines of the general formula ##STR1## in which R is methyl or ethyl, R.sub.1 is hydrogen or methyl and R.sub.2 is methylthio, methylsulfinyl oder methoxy, and their pharmaceutically acceptable acid addition salts, which compounds possess pharmacological properties, especially a positively inotropic activity on the heart.

REFERENCES:
patent: 4336257 (1982-06-01), Baldwin
Hofman, Imidazole and it's Derivatives, vol. 1, Interscience Pub. (1953).
March, Advanced Organic Chemistry, 1st Ed., McGraw-Hill, 1977, p. 887.
Geiser & Williamson, Organic Experiments, 4th Ed., p. 50
Chemical Abstracts, vol. 62, 1965, item 4022b, Garmaise et al.

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