Process for production of N-acyl-.alpha.-amino acids

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

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260404, 546268, 546281, 546284, 546323, 546335, 548492, 548494, 548495, 548517, 548527, 548537, 549 60, 549 69, 549 72, 549 76, 549487, 549493, 562497, 562517, C07C 5112

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044979649

ABSTRACT:
A process for the production of an N-acyl-.alpha.-amino acid represented by the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4, independently from each other, represent a hydrogen atom, an alkyl or cycloalkyl group which may be substituted, or an aryl or heteroaromatic group selected from the group consisting of furyl, pyrrolyl, pyridinyl, thienyl and indolyl which may be substituted, which comprises reacting an oxirane represented by the general formula ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, an amide compound represented by the general formula

REFERENCES:
patent: 3766266 (1973-10-01), Wakamatsu
patent: 4264515 (1981-04-01), Stern
Hawley, "The Condensed Chemical Dictionary," 8th Ed., pp. 28, 80 and 657 (1971).

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