N-Oxide compounds useful in the treatment of cardiovascular ailm

Details N-Oxide compounds useful in the treatment of cardiovascular ailm N-Oxide compounds useful in the treatment of cardiovascular ailm

1982-12-27

1985-02-05

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544 584, 544 586, 544131, 544364, 546116, 546121, 546187, 546193, 546194, 546256, 546257, 514238, 514252, 514333, 514334, A61K 3144, C07D21389, C07D491048

Patent

active

044978081

ABSTRACT:
The present invention relates to novel N-oxide compounds that have cardiovascular properties, especially antihypertensive activity, and that correspond to the formula ##STR1## in which Py represents an unsubstituted or substituted N-oxidopyridyl radical, R.sub.1 represents hydrogen or unsubstituted or substituted lower alkyl, one of the radicals R.sub.2 and R.sub.3 represents lower alkyl and the other represents hydrogen; lower alkyl; lower alkyl containing free, etherified or esterified hydroxy, oxo, functionally modified carboxy or free or substituted amino or imino; functionally modified carboxy; or free or substituted amino, it being possible for an amino group R.sub.2 or R.sub.3 to be bonded to a lower alkyl radical R.sub.1 or, if R.sub.2 or R.sub.3 represents, for example, hydroxy-lower alkyl, for this hydroxy-lower alkyl, together with the adjacent acyl radical Ac.sub.1 or Ac.sub.2, to form a 2-oxa-1-oxo-lower alkylene radical, the carbonyl group of which is bonded to the 3- or 5-ring carbon atom of the 1,4-dihydropyridine ring, and each of the groups Ac.sub.1 and Ac.sub.2 represents, independently of the other, the acyl radical of an acid, and salts of compounds of the formula I having salt-forming groups, processes for the manufacture of these compounds, the use of these compounds and their salts, and pharmaceutical preparations which contain these compounds and salts, as antihypertensive agents and coronary dilators for the treatment of cardiovascular conditions, such as hypertonia, vascular constrictions, Angina pectoris and cardiac insufficiency.

REFERENCES:
patent: 3775422 (1973-11-01), Bossert et al.
patent: 3862161 (1975-01-01), Bossert et al.
patent: 3883540 (1975-05-01), Meyer et al.
patent: 3905983 (1975-09-01), Bossert et al.
patent: 3920823 (1975-11-01), Meyer et al.
patent: 3933834 (1976-01-01), Meyer et al.
patent: 3946027 (1976-03-01), Bossert et al.
patent: 3966948 (1976-06-01), Bossert et al.
patent: 4145432 (1979-03-01), Sato

Affiliated with

Also associated with

Rating

N-Oxide compounds useful in the treatment of cardiovascular ailm does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N-Oxide compounds useful in the treatment of cardiovascular ailm, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-Oxide compounds useful in the treatment of cardiovascular ailm will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2082518