Tricyclic inhibitors of the vitronectin receptor

Details Tricyclic inhibitors of the vitronectin receptor Tricyclic inhibitors of the vitronectin receptor

1995-05-08

1998-02-10

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514220, 540497, 540498, A61K 3155, C07D24314

Patent

active

057169519

ABSTRACT:
A tricylic benzodiazepine derivative that acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPII.sub.b III.sub.a receptor and is provided in therapeutic compositions for the treatment of diseases for which blocking platelet aggregation is indicated. These nonpeptidyl inhibitors are provided in combination with thrombolytics and anticoagulants.

REFERENCES:
patent: 5250679 (1993-10-01), Blackburn et al.
patent: 5403836 (1995-04-01), Blackburn et al.
patent: 5493020 (1996-02-01), Blackburn et al.
Ager et al., "Central Nervous System Activity of a Novel Class of Annelated (1977).
Hawiger, "Platelet-Vessel Wall Interactions Platelet Adhesion and Aggregation" Atherosclerosis Reviews 21:165-186 (1990).
Hynes, "Integrins: A Family of Cell Surface Receptors" Cell 48:549-554 (1987).
Kieffer et al., "Platelet Membrane Glycoproteins: Functions in Cellular Interactions" Annu. Rev. Cell Biol. 6:329-357 (1990).
Roth, "Platelets and blood vessels: The adhesion event" Immunology Today 13(3):100-105 (1992).
Ruoslahti, "Integrins" J. Clin. Invest. 87:1-5 (1991).

Affiliated with

Also associated with

Rating

Tricyclic inhibitors of the vitronectin receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tricyclic inhibitors of the vitronectin receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tricyclic inhibitors of the vitronectin receptor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2077518