Process for producing 7-alkoxycarbonyl-6,8-dimethyl-4-hydroxymet

Details Process for producing 7-alkoxycarbonyl-6,8-dimethyl-4-hydroxymet Process for producing 7-alkoxycarbonyl-6,8-dimethyl-4-hydroxymet

1980-07-23

1982-09-21

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

549304, 549305, C07D23732

Patent

active

043508138

ABSTRACT:
A novel process for producing 7-alkoxycarbonyl-6,8-dimethyl-4-hydroxymethyl-1-phthalazone, and its intermediates. 7-Alkoxycarbonyl-6,8-dimethyl-4-hydroxymethyl-1-phthalazone can be obtained by reacting substituted methylenetriphenylphosphorane with 3,5-dimethyl-4-alkoxycarbonylphthalic anhydride to obtain 6-alkoxycarbonyl-5,7-dimethyl-.DELTA..sup.3,.alpha. -substituted methylenephthalide, reacting the latter with hydrazine to obtain a phthalazone derivative, hydrolyzing the latter, halogenating the hydrolyzate to obtain 7-alkoxycarbonyl-6,8-dimethyl-4-(.alpha.-halogeno-.alpha.-substituted methyl)-1-phthalazone and then directly hydrolyzing and decarboxylating the latter or, when said 7-alkoxycarbonyl-6,8-dimethyl-4-(.alpha.-halogeno-.alpha.-substituted methyl)-1-phthalazone is 7-alkoxycarbonyl-6,8-dimethyl-1-phthalazone-4-.alpha.-halogenoacetic acid, reacting it with a carboxylic acid salt such as sodium acetate and simultaneously decarboxylating the acyloxylated compound and then hydrolyzing the decarboxylated product or firstly decarboxylating the 1-phthalazone-4-.alpha.-halogenoacetic acid derivative, reacting the decarboxylated product with said carboxylic acid salt and then hydrolyzing the reaction product or when said 7-alkoxycarbonyl-6,8-dimethyl-4-(.alpha.-halogeno-.alpha.-substituted methyl)-1-phthalazone is 7-alkoxycarbonyl-4-(.alpha.-carbamoyl-.alpha.-halogenomethyl)-6,8-dimethyl -1-phthalazone, reacting it with said carboxylic acid salt and then hydrolyzing and decarboxylating the acyloxylated compound simultaneously.

REFERENCES:
Foldeak et al., Chem. Abs. 72, 100626p.

Affiliated with

Also associated with

Rating

Process for producing 7-alkoxycarbonyl-6,8-dimethyl-4-hydroxymet does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for producing 7-alkoxycarbonyl-6,8-dimethyl-4-hydroxymet, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for producing 7-alkoxycarbonyl-6,8-dimethyl-4-hydroxymet will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2077050