Substituted azetidinone aldehydes

Details Substituted azetidinone aldehydes Substituted azetidinone aldehydes

1976-10-01

1978-01-31

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260307F, 544 90, C07D20508

Patent

active

040715132

ABSTRACT:
Chemical transformation of the dihydrothiazine ring of a cephalosporin into the dihydrooxazine ring (1-oxacephem) was accomplished utilizing the novel intermediate having the structure ##STR1## wherein R is an amino-protecting group and R.sup.1 is the residue of an ester group which can be removed readily without disrupting the remainder of the molecule as illustrated by phenoxyacetyl as R and benzhydryl as R.sup.1.

REFERENCES:
patent: 3948927 (1976-04-01), Wolfe
S. Wolfe et al., CAN J. Chem. 52, 3996 (1974).
Derwent Farmdoc No. D0109X, 38606V and 38607V.
Cama et al., J. Amer. Chem. Soc., 96, 7582 (1974).
D. O. Spry, Tetrahedron Letters, 1972, p. 3717.
S. Kukolja, J. Amer. Chem. Soc., 93, 6267 (1971).
D. F. Corbeltt, J. Chem. Soc. Perkin I 185, (1974) and 432 (1975).
R. F. Borch et al., J. Amer. Chem. Soc., 93, 2897 (1971).

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