Imidazole derivatives, process for their preparation and pharmac

Details Imidazole derivatives, process for their preparation and pharmac Imidazole derivatives, process for their preparation and pharmac

1981-02-17

1982-09-21

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424263, 424269, 424270, 544331, 546278, 548195, 548251, C07D40312, C07D41712, A61K 31505, A61K 31415

Patent

active

043506968

ABSTRACT:
Compounds of the general formula: ##STR1## wherein X is a group of the formula: ##STR2## m is 2 or 3; n is an integer of from 1 to 4; and R is a 5-membered heterocyclic group containing as heteroatoms a nitrogen atom and an additional oxygen or sulphur atom or up to three further nitrogen atoms; or a 6-membered heterocyclic group containing one or two nitrogen atoms;
and the pharmaceutically acceptable acid addition salts thereof, are able to selectively inhibit the action of the thromboxane synthetase enzyme without significantly inhibiting the action of the prostacycline synthetase or cyclo-oxygenase enzymes and are thus useful in the treatment of ischaemic heart disease, stroke, transient ischaemic attack, thrombosis, migraine and the vascular complications of diabetes.

REFERENCES:
patent: 3862163 (1975-01-01), Boroschewski et al.
patent: 4230714 (1980-10-01), Cross et al.
patent: 4238493 (1980-12-01), Roantree et al.

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