Platelet derived cell growth factor

Details Platelet derived cell growth factor Platelet derived cell growth factor

1980-02-10

1982-09-21

Naff, David M.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

435 68, 435240, 435241, 260112R, A61K 3702, C07G 700, C12N 500, C12P 2100

Patent

active

043506879

ABSTRACT:
A purified cell growth factor is produced which comprises a substantially purified glycoproteinaceous factor from platelets which has mitogenic activity toward transformed cells, a molecular weight of 3,000-5,000 daltons and a pI of 7.8-8.3. The growth factor is stable to treatment with 4M guanidine hydrochloride, and is heat labile when treated at 100.degree. C. for 5 minutes.

REFERENCES:
patent: 4261976 (1981-04-01), Isselbacher et al.
patent: 4269825 (1981-05-01), Bohn et al.
Kohler et al. Experimental Cell Research 87 (1974) pp. 297-301.
Kepner et al., Platelets As A Source of Cell-Proliferating Activity Platelets, Raven (1978) 205-212.

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