Antitumor antibiotics aclacinomycins A and B [RD-9187A]

Details Antitumor antibiotics aclacinomycins A and B [RD-9187A] Antitumor antibiotics aclacinomycins A and B [RD-9187A]

1976-06-04

1978-01-31

Jones, Raymond N.

Textiles: fiber preparation

C12D 914

Patent

active

040714110

ABSTRACT:
New antitumor agents named aclacinomycins A and B, which are anthracycline glycosides and inhibit the growth of various microorganisms e.g., Staphylococcus aureus, Micrococcus flavus, Corynebacterium bovis and inhibit the growth of animal tumors such as leukemia L1210 and P388 and lymphoma 6C3HED in mice and hepatomas in rats are produced by the fermentation of a microorganism belonging to the genus Streptomyces which has been designated Streptomyces galilaeus (MA144-M1 and A.T.C.C. 31133); they are recovered from the broth by conventional methods for recovering antibiotics.

REFERENCES:
patent: 3989820 (1976-11-01), Florent et al.
Gottlieb et al., "Antibiotics", vol. I, Springer-Verlag, New York, 1967, pp. 190-204.
Berg et al., Chem. Abstracts, vol. 73, 1970, p. 54, Abs. No. 265r.
Keller-Schierlein et al., Antimicrobial Agents and Chemotherapy, 1970, pp. 68-74.
Eckardt et al., "Isolation and Structure of Two New Anthracyclinones from Streptomyces galilaeus Cultures," Chem. Abstracts, vol. 81, (1974), p. 92, Abs. No. 1090p.
Eckardt, "Red Antibiotics from Actinomycetes, Identification of a series of Anthracyclone Pigments from Streptomyces galilaeus Strain JA3043 (galirubin and galirubinone)", Chem. Abstracts, vol. 67, (1967), pp. 8514, 8515, Abs. No. 90573z.
Bradler et al., "Characterization of Streptomyces Strain JA3043, and Recovery of galirubin and galirubinone," Chem. Abstracts, vol. 69, (1968), p. 6906, Abs. No. 74035m.

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