Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-12-04
2000-11-14
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514396, 514397, 514398, 514399, 5462714, 5483225, 5483235, 5483241, 5483245, 5483251, 5483325, 5483381, 5483441, A61K 314164, A61K 314412, C07D23364, C07D40106
Patent
active
06147097&
ABSTRACT:
An imidazole derivative represented by general formula (I) or a salt thereof, having the effect of specifically inhibiting the growth of HIV as a pathogenic virus and being reduced in toxicity. In said formula R.sup.1 represents hydrogen, C.sub.1 -C.sub.20 alkyl, C.sub.2 -C.sub.7) alkenyl, C.sub.4 -C.sub.12 cycloalkylalkyl, etc.; R.sup.2 represents C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 acyl, hydroxyiminomethyl, hydrazonomethyl or --(CH.sub.2)n--R.sup.4 (R.sup.4 being halogeno, alkoxy, hydroxy, etc.; and n being an integer of 1 to 3); R.sup.3 represents substituted or unsubstituted C.sub.1 -C.sub.6 alkyl; X and Y represent each independently hydrogen, C.sub.1 -C.sub.3 alkyl, halogeno, or nitro; and Z represents S, SO, SO.sub.2 or CH.sub.2. ##STR1##
REFERENCES:
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Masaichiro Masui et al.; "Reactions of N-(1-cyanoalkyl)alkylideneamine N-oxides with dipolarophles and nucleophiles", Part I; Journal of the Chemical Society, Perkin Transactions 1, 1972, pp. 1955-1960, pp. 1957 and 1959, compound IIId.
Masaichiro Masui et al.; "Convenient syntheses of 2,4(5)-dialkylimidazoles and 1-methyl-2,4-dialkylimidazoles", Journal of the Chemical Society, Perkins Transactions 1, 1972, pp. 1960-1963.
Fujiwara Tamio
Sugimoto Hirohiko
Raymond Richard L.
Shionogi & Co. Ltd.
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