Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-02-25
2000-11-14
Fan, Jane
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514333, 5462731, 546256, C07D40104, A61K 314427
Patent
active
061470961
ABSTRACT:
This invention provides compounds, and pharmaceutically acceptable salts thereof, having the structure shown below, as well as related pharmaceutical compositions, and methods of treatment and synthesis. ##STR1##
REFERENCES:
C. Dinarello et al., Inflammatory cytokines: Interleukin-1 and Tumor Necrosis Factor as Effector Molecules in Autoimmune Diseases, Curr. Opin. Immunol. 1991, 3, 941-48.
M.J. Elliot et al., Treatment of Rheumatoid Arthritis with Chimeric Monoclonal Antibodies to Tumor Necrosis Factor .alpha., Arthritis Rheum. 1993 36, 1681-90.
J.C. Boehm et al., 1-Substituted 4-Aryl-5-pyridinylimidazoles: A New Class of Cytokine Suppressive Drugs with Low 5-Lipoxygenase and Cyclooxygenase Inhibitory Potency, J. Med. Chem., 1996, 39, 3929-37.
A.M. Badger, et al., Pharmacological Profile of SB 203580, A Selctive Inhibitor of Cytokine Suppressive Binding Protein/p38 Kinase, in Animal Models of Arthritis, Bone Resorption, and Immune Function, The Journal of Pharmacology and Experimental Therapeutics, 1996, 279, 1453-61.
Gallagher, T.F. et al., Regulation of Stress-Induced Cytokine Production by Pyridinylimidazoles; Inhibition of CSBP Kinase, Bioorganic& Medicinal Chemistry, 1997, 5, 49-64.
Chetverikov, V.P. et al., Synthesis of 2-imidazo[4,5-e]indoles from 5-aminobenzimidazoles, Zhim. Geterotsiki. Soedin, 1980, 1, 74-8.
Lantos, I. et al., Synthetic and Mechanistic Studies on the Preparation of Pyridyl-Substituted Imidazothiazoles, J. Org. Chem., 1988, 53, 4223-27.
Dodd John H.
Henry James R.
Rupert Kenneth C.
Fan Jane
Morrison Alan J.
Ortho -McNeil Pharmaceutical, Inc.
LandOfFree
Substituted pyrrolobenzimidazoles for treating inflammatory dise does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted pyrrolobenzimidazoles for treating inflammatory dise, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted pyrrolobenzimidazoles for treating inflammatory dise will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2065777