Polycyclic ether antibiotics

Details Polycyclic ether antibiotics Polycyclic ether antibiotics

1988-02-08

1991-02-12

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 168, 536 187, 435825, 426658, A61K 3171, C07H 1704, C12P 1718, A23G 300

Patent

active

049924230

ABSTRACT:
A new acidic polycyclic ether antibiotic UK-58,852 has the formula: ##STR1## wherein R and R.sup.1 are both hydrogen, and can be prepared by the submerged aerobic propagation in aqueous nutrient media of Actinomadura sp. ATCC 39697. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization is swine and ruminants. Two minor components, where R is H and R.sup.1 is CH.sub.3 and wherein R and R.sup.1 are both CH.sub.3, have also been isolated from the fermentation.

REFERENCES:
patent: 4278663 (1981-07-01), Liu et al.
patent: 4565862 (1986-01-01), Foley et al.

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