Chemistry: analytical and immunological testing – Nuclear magnetic resonance – electron spin resonance or other...
Patent
1996-07-03
1999-02-16
Soderquist, Arlen
Chemistry: analytical and immunological testing
Nuclear magnetic resonance, electron spin resonance or other...
422 58, 422 59, 422 681, 422 69, 422 70, 422 10, 436 52, 436 86, 436 87, 436 89, 436 91, 436 93, 436 94, 436161, 436172, 436174, 436175, 436177, 436183, 2101982, G01N 2400, G01N 3000
Patent
active
058720103
ABSTRACT:
A microscale fluid handling system that permits the efficient transfer of nanoliter to picoliter quantities of a fluid sample from the spatially concentrated environment of a microfabricated chip to "off-chip" analytical or collection devices for further off-chip sample manipulation and analysis is disclosed. The fluid handling system is fabricated in the form of one or more channels, in any suitable format, provided in a microchip body or substrate of silica, polymer or other suitable non-conductive material, or of stainless steel, noble metal, silicon or other suitable conductive or semi-conductive material. The microchip fluid handling system includes one or more exit ports integral with the end of one or more of the channels for consecutive or simultaneous off-chip analysis or collection of the sample. The exit port or ports may be configured, for example, as an electrospray interface for transfer of a fluid sample to a mass spectrometer.
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Dunayevskiy Yuriy M.
Foret Frantisek
Karger Barry L.
McGruer E. Nicol
Xue Qifeng
Northeastern University
Soderquist Arlen
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