Cloning of a novel G-Protein coupled 7TM receptor

Details Cloning of a novel G-Protein coupled 7TM receptor Cloning of a novel G-Protein coupled 7TM receptor

1997-01-24

1999-02-16

Ulm, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 71, 4352523, 4353201, 536 235, C12N 1512

Patent

active

058719679

ABSTRACT:
HNHCI32 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HNHCI32 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

REFERENCES:
Buck et al., "A Novel Multigene Family May Encode Odorant Receptors: A Molecular Basis for Odor Recognition", Cell 65:175-187, Apr. 5, 1991.
Oliveira et al.; "A Common Motif in G-Protein-Coupled Seven Transmembrane Helix Receptors", Journal of Computer-Aided Molecular Design, vol. 7(6), pp. 649-658 (1993).
Hamblin, M. W. and Metcalf, M. A., "Primary Structure and Functional Characterization of a Human 5-HT1D-Type Serotonin Receptor", Mol. Pharmacol., 1991, 40:143-148. GenBank Accession No.: M89955.
Voigt, M. M., et al., "Sequence of a Rat Brain cDNA Encoding an Alpha-1B Adrenergic Receptor", Nucleic Acids Res., 1990, 18(4):1053. GenBank Accession No.: X51585.
Zgombicvk, J. M., et al., "Human Gene S31 Encodes the Pharmacologically Defined Serotonin 5-Hydroxytryptamine 1E Receptor", Mol. Pharmacol., 1992, 42(2):180-185. GenBank Asscession No.: M92826.
Levy, F., et al., "Molecular Cloning of a Human Gene (S31) Encoding a Novel Serotonin Receptor Mediating Inhibition of Adenylyl Cyclase", FEBS Lett., 1992, 296(2):201-206. GenBank Accession No.: Z11166.
Kalkman, H. et al., "5HT receptor types and their role in disease", Current Opinion in Neutrology and Neurosurgery, 4:560-565 (1991).
Bockaert, J. et al., "The 5-HT.sub.4 receptor: a place in the sun", TiPS Reviews, vol. 13, pp. 141-145 (1992).
David Juius, "Molecular Biology of Serotonin Receptors", Annu. Rev. Neurosci., 14:335-360 (1991).

Affiliated with

Also associated with

Rating

Cloning of a novel G-Protein coupled 7TM receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cloning of a novel G-Protein coupled 7TM receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cloning of a novel G-Protein coupled 7TM receptor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2061392