Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Patent
1996-01-26
1999-02-16
Hutzell, Paula K.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
435 71, 435 721, G01N 3353
Patent
active
058717129
ABSTRACT:
The invention provides methods for detecting calpain activation by measuring levels of calpain-generated spectrin BDPs using antibodies that specifically bind to these spectrin BDPs, but not intact spectrin, or spectrin BDPs generated by other proteases. Also included in the invention are kits for diagnosing diseases associated with increased levels of calpain activation, and methods for screening for effective therapeutics for these diseases.
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Cephalon Inc.
Duffy Patricia A.
Hutzell Paula K.
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