Human monoclonal antibodies to cell surface antigens

Details Human monoclonal antibodies to cell surface antigens Human monoclonal antibodies to cell surface antigens

1984-06-01

1987-09-22

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

424 11, 424 3, 424 7, 435 68, 4351722, 43524027, 935 89, 935 93, 935 95, 935 96, 935 99, 935100, 935101, 935106, 935107, 935108, 935110, 436501, 436504, 436536, 436537, 436518, 436548, 436813, 436828, G01N 3353, G01N 33577

Patent

active

046955380

ABSTRACT:
Human monoclonal antibodies (HmAbs) capable of reacting with cell surface antigens and intracellular components are disclosed. It has been found that HmAbs Ev248, Ch-5, Ch-13, Te-39, Hu44, Ge-1, Gr-431, Gr169 and Sp909 may be used to detect these antigens in various cells. By means of these HmAbs malignant cells may be determined. This information may be used to screen metastasized tumors and primary tumors for tissue source and greatly affects the management of these cancers.

REFERENCES:
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patent: 4529694 (1985-07-01), Lazarus et al.
Houghton et al., J. Exp. Med., 158 (Jul. 1983) 53-65.
Cote et al., Proc. Natl. Acad. Sciences U.S.A., 80 (Apr. 1983), 2026-30.
Dippold et al., Proc. Natl. Acad. Sci. U.S.A., 77 (Oct. 1980), 6114-8.
Daar et al., The Lancet, Aug. 29, 1981, 434-8.
Croce et al., Proc. Natl. Acad. Sci. U.S.A., 76 (Jul. 1979), 3416-9.

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