Competitive inhibitors of glyoxalase I and method of generating

Details Competitive inhibitors of glyoxalase I and method of generating Competitive inhibitors of glyoxalase I and method of generating

1998-01-07

1999-10-19

Tsang, Cecilia J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Esters having the thiocarboxylate group, -cx-, wherein the...

514365, 514415, 548146, 546201, 549 29, 549200, 560312, C07C33300

Patent

active

059691743

ABSTRACT:
The present invention provides a compound having the structure ##STR1## wherein S* is S.dbd.O or O.dbd.S.dbd.O; and wherein R.sub.1 is selected from the group consisting of (C.sub.1 -C.sub.9) alkyl, (C.sub.3 -C.sub.8) cycloalkyl, (C.sub.5 -C.sub.7) cycloalkenyl, and (C.sub.6 -C.sub.20) aryl substituted with halogen or (C.sub.1 -C.sub.18) alkyl; and wherein R.sub.2 is selected from the group consisting of alkyl, (C.sub.1 -C.sub.9) alkyl, (C.sub.3 -C.sub.8) cycloalkyl, (C.sub.5 -C.sub.7) cycloalkenyl, and (C.sub.6 -C.sub.20) aryl substituted with halogen or (C.sub.1 -C.sub.18) alkyl. Also provided are various methods of using the compositions of the present invention.

REFERENCES:
patent: 5616563 (1997-04-01), Creighton

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