Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-08-23
1998-04-21
Elliott, George G.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4351723, 4352523, 4353201, 435325, 536 235, 536 2431, C12N 1512, C12N 1510, C12N 1563
Patent
active
057416664
ABSTRACT:
The present invention relates to methods and compositions for the treatment of body weight disorders, including, but not limited to, obesity. Specifically, the present invention identifies and describes genes which are differentially expressed in body weight disorder states, relative to their expression in normal, or non-body weight disorder states, and/or in response to manipulations relevant to appetite and/or weight regulation. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in body weight disorders and/or appetite and/or body weight regulation. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of body weight disorders. Additionally, the present invention describes methods for the diagnostic evaluation and prognosis of various body weight disorders, and for the identification of subjects exhibiting a predisposition to such conditions.
REFERENCES:
Goldberger et al. "Human Complement Factor I: Analysis of cDNA-derived Primary Structure and Assignment of Its Gene to Chromosome 4", The Journal of Biological Chemistry, vol. 262, No. 21, pp. 10065-10071, Jul. 25, 1987.
Bouillard et al. "Complete cDNA-derived Amino Acid Sequence of Rat Brown Fat Uncoupling Protein", The Journal of Biological Chemistry, vol. 261, No. 4, pp. 1487-1490, Feb. 5, 1986.
Elliott George G.
Millennium Pharmaceuticals Inc.
Railey II Johnny F.
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