Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis
Patent
1983-03-25
1987-09-22
Apley, Richard J.
Prosthesis (i.e., artificial body members), parts thereof, or ai
Implantable prosthesis
623 1, 623 16, A61F 202, A61F 206
Patent
active
046952810
ABSTRACT:
The medical material according to this invention contains collagen, which as been chemically modified by saccinylation of thermal --NH.sub.2 groups of said chains attached to poly peptide chains of the collagen so that the --NH.sub.2 groups are converted into groups having --COOH groups. This succinylation can be carried out by reacting succinic anhydride with the --NH.sub.2 groups of the collagen. Since the above medical material has excellent compatibility with living bodies, especially, with blood, it is suitable to use it as a replacement material for tissues and/or organs which are kept in contact with blood at their surfaces, namely, is suitable for use in artificial blood vessels, artificial valves, some parts of artificial hearts which are kept in contact with blood at said parts, etc. and as a patching material for hearts.
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Noishiki et al., "Initial Healing Process of Succinylated Collagen Tube as an Antithrombogenic Cardiovascular Graft", 8th Annual Meeting of the Society for Biomaterials, Walt Disney World, Apr. 24, 27, 1982.
Sawyer et al., "Experimental and Clinical Evaluation of a New Negatively Charged Bovine Heterograft for Use in Peripheral and Coronary Revascularization", Vascular Grafts, Appleton-Century Crofts/New York (1978).
Miyata Teruo
Noishiki Yasuharu
Apley Richard J.
Isabella David
Koken Co. Ltd.
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