Alkylaminoalkyl-sulfonyl-terminated .beta.-alanineamide amino-di

Details Alkylaminoalkyl-sulfonyl-terminated .beta.-alanineamide amino-di Alkylaminoalkyl-sulfonyl-terminated .beta.-alanineamide amino-di

1997-07-14

1999-10-19

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564154, A61K 3116, A61K 31165, C07C32341

Patent

active

059689846

ABSTRACT:
Compounds characterized generally as alkylaminoalkyl-terminated .beta.-alanineamide amino diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of the formula ##STR1## wherein n is two or three; wherein x is a number selected from zero, one and two; wherein R.sup.2 is selected from hydrido, methyl, ethyl and phenyl; wherein R.sup.3 is selected from hydrido, cyclohexylmethyl, benzyl, fluorobenzyl, chlorobenzyl, napthylmethyl, fluoronaphthylmethyl and chloronaphthylmethyl; wherein R.sup.5 is methyl; wherein R.sup.7 is cyclohexylmethyl; wherein R.sup.8 is selected from n-propyl, isobutyl, cyclopropyl, cyclopropylmethyl, allyl and vinyl; and wherein each of R.sup.9 and R.sup.10 is a group independently selected from methyl, ethyl and isopropyl; or a pharmaceutically-acceptable salt thereof.

REFERENCES:
patent: 4900745 (1990-02-01), Hanson et al.
patent: 4900746 (1990-02-01), Hanson et al.
patent: 4902706 (1990-02-01), Hanson et al.
patent: 4914129 (1990-04-01), Buhlmayer et al.
patent: 4931429 (1990-06-01), Hanson et al.
patent: 5032577 (1991-07-01), Fung et al.
patent: 5089471 (1992-02-01), Hanson et al.
patent: 5246969 (1993-09-01), Hanson et al.
patent: 5268391 (1993-12-01), Hanson et al.
patent: 5312838 (1994-05-01), Chen et al.
patent: 5314920 (1994-05-01), Chen et al.
patent: 5432201 (1995-07-01), Hanson et al.
Umezawa et al, in J. Antibiot. (Tokyo), 23, 259-262 (1970).
Gross et al, Science, 175, 656 (1971).
Boger et al, Nature, 303, 81 (1983).
Kokubu et al, Biochm. Biophys. Res. Commun., 118, 929 (1984).
Castro et al, FEBS Lett. , 167, 273 (1984).
Hanson et al, Biochm. Biophys. Res. Comm. 132, 155-161 (1985).
Hanson et al, Biochm. Biophys. Res. Comm., 146 959-963 (1987).

Affiliated with

Also associated with

Rating

Alkylaminoalkyl-sulfonyl-terminated .beta.-alanineamide amino-di does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Alkylaminoalkyl-sulfonyl-terminated .beta.-alanineamide amino-di, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alkylaminoalkyl-sulfonyl-terminated .beta.-alanineamide amino-di will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2056011