Nuclear cyclophilin

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Isomerase

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4352523, 43525411, 4353201, 536 232, C12N 990, C12N 121, C12N 1563, C07H 2104

Patent

active

059688025

ABSTRACT:
Cyclophilin-60 proteins, nucleic acids, and monoclonal antibodies are provided.

REFERENCES:
Thall, M., et al., "Functional association of cyclophilin A with HIV-1 virions", Nature, 372:363-365 (1994).
Gabay, J. E., et al., "Antibiotic peptides and serine protease homologs in human polymorphonuclear leukocytes: defensins and azurocidin", Current Opinion in Immunology, 5:97-102 (1993).
Luban, J., et al., "Human Immunodeficiency Virus Type 1 Gag Protein Binds to Cyclophilins A and B", Cell, 73:1067-1078 (1993).
Stamnes, M. A., et al., "The Cyclophilin Homolog ninaA Is a Tissue-Specific Integral Membrane Protein Required for the Proper Synthesis of a Subset of Drosophila Rhodopsins", Cell, 65:219-227 (1991).
Franke, E. K., et al., "HIV-1 Uses Host-Cell Proteins To Form Fully Infectious Virions", The Journal of NIH Research, 7:37-42 (1995).
Liu, J., et al., "Human and Escherichia coli Cyclophilins: Sensitivity to Inhibition by the Immunosuppressant Cyclosporin A Correlates with a Specific Tryptophan Residue", Biochemistry 30:2306-2310 (1991).
Bram, R. J., et al., "Identification of the Immunophilins Capable of Mediating Inhibition of Signal Transduction by Cyclosporin A and FK506: Roles of Calcineurin Binding and Cellular Location", Molecular and Cellular Biology, 13(8):4760-4769 (1993).
Fields, S., et al., "A novel genetic system to detect protein-protein interactions", Nature, 340:245-246 (1989).
Azhderian, E. M., et al., "Nuclear Membrane-Associated Cyclophilins of Potential Importance in Cyclosporine Immunosuppression", Transplantation Proceedings, 25(1):524-526 (1993).
O'Keefe, S. J., et al., "FK-506-and CsA-sensitive activation of the interleukin-2 promoter by calcineurin", Nature, 357:692-694 (1992).
Clipsonte, N. A., et al., "Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation", Nature, 357:695-697 (1992).
Vojtek, A. B., et al., "Mammalian Ras Interacts Directly with the Serine/Threonine Kinase Raf", Cell, 74:205-214 (1993).
Bram, R. J., et al., "Calcium signalling in T cells stimulated by a cyclophilin B-binding protein", Nature, 371:355-358 (1994).
Wang, T., et al., "Specific Interaction of Type I Receptors of the TGF-.beta. Family with the Immunophilin FKBP-12", Science, 265:674-676 (1994).
Walsh, C. T., et al., "Cyclosporin A, the Cyclophilin Class of Peptidylprolyl Isomerases, and Blockage of T Cell Signal Transduction", The Journal of Biological Chemistry, 267(19):13115-13118 (1992).
Franke, E. K., et al., "Specific incorporation of cyclophilin A into HIV-1 virions", Nature, 372:359-362 (1994).
Sigal, N. H., et al., "Cyclosporin A, FK-506, and Rapamycin: Pharmacologic Probes of Lymphocyte Signal Transduction", Annu. Rev. Immunol., 10:519-60 (1992).
Fruman, D. A., et al., "Immunophilins in protein folding and immunosuppression", The FASEB Journal, 8:391-400 (1994).
Snyder, S. H., et al., "Immunophilins and the nervous system", Nature Medicine, 1(1):32-37 (1995).
Liu, J., et al., "Calcineurin Is a Common Target of Cyclophilin-Cyclosporin A and FKBP-FK506 Complexes", Cell, 66:807-815 (1991).
Cullen, B. R., et al., "Chaperoning a pathogen", Nature, 372:319-320 (1994).
Trandinh, C. C., et al., "Structural and evolutionary relationships among the immunophilins: two ubiquitous families of peptidyl-prolyl cis-trans isomerases", The FASEB Journal, 6:3410-3420 (1992).
Rinfret, Aline, et al., "The N-Terminal Cyclophilin-Homologous Domain of a 150-Kilodalton Tumor Recognition Molecule Exhibits Both Peptidylprolyl cis-trans-Isomerase and Chaperone Activities." Biochemistry, 33(7):1668-1673 (1994).
Price, E. Roydon, et al., "Cyclophilin B Trafficking Through the Secretory Pathway is Altered by Binding of Cyclosporin A." Proc. Natl. Acad. Sci. USA, 91:3931-3935 (1994).
Nair, Asha P., et al., "Cyclosporin A Inhibits Growth of Autocrine Tumor Cell Lines by Destabilizing Interleukin-3 mRNA." Nature, 369:239-242 (1994).
Ryffel, B., et al., "Distribution of the Cyclosporin Binding Protein Cyclophilin in Human Tissues." Immunology, 72:399-404 (1991).
Schneider, Helmut, et al., "Human Cyclophilin C: Primary Structure, Tissue Distribution, and Determination of Binding Specificity for Cyclosporins." Biochemistry, 33:8218-8224 (1994).
Pflugl, Gaston, et al., "X-Ray Structure of a Decameric Cyclophilin-Cyclosporin Crystal Complex." Nature, 361:91-94 (1993).
Kahan, Barry D., "Cyclosporine." Medical Intelligence, 321(25):1725-1738 (1989).
Mason, June, "Pharmacology of Cyclosporine (Sandimmune) VII. Pahtophysiology and Toxicology of Cyclosporine in Humans and Animals." Pharmacological Reviews, 42(3):423-434 (1989).
Wilson, R., et al., "2.2 Mb of Contiguous Nucleotide Sequence from Chromosome III of C. elegans." Nature, 368:32-38 (1994).
Baker, E., "The Cyclophilin Homolog NinA Functions as a Chaperone, Forming a Stable Complex in vivo with its Protein Target Rhodopsin." The EMBO Journal, Sequencing Project submitted to the EMBL/GenBank/DDBJ databases.
Seemuller, Ursula, "Structure of the Elastase-Cathepsin G Inhibitor of the Leech Hirudo medicinalis." Hoppe-Seyler's Z. Physiol. Chem., 361:1841-1846 (1980).
Price, E. Roydon, et al., "Human Cyclophilin B: A Second Cyclophilin Gene Encodes a Peptidyl-Prolyl Isomerase with a Signal Sequence." Proc. Natl. Acad. Sci. USA, 88:1903-1907 (1991).
Fischer, Gunter, "Cyclophilin and Peptidyl-Prolyl cis-trans Isomerase are Probably Identical Proteins." Nature, 337:476-478 (1989).
Freskgard, Per-Ola, "Isomerase and Chaperone Activity of Prolyl Isomerase in the Folding of Carbonic Anhydrase." Science, 258:466-468 (1992).
Emmel, Elizabeth A., "Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation." Science, 246:1617-1620 (1989).
Nomura, N., et al., "Prediction of the Coding Sequences of Unidentified Human Genes. II. The Coding Sequences of 40 New Genes (KIAA 0041 -KIAA 0080) Deduced by Analysis of Randomly Sampled cDNA Clones from Human Immagure Myeloid Cell Line KGI." Unpublished (1994).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Nuclear cyclophilin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nuclear cyclophilin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nuclear cyclophilin will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2054840

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.