Human GPI2 homolog

Details Human GPI2 homolog Human GPI2 homolog

1997-05-22

1999-10-19

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435183, 4352523, 4353201, 435325, 536 232, 536 235, C12Q 168, C12N 900, C12N 120, C07H 2104

Patent

active

059687428

ABSTRACT:
The present invention provides a new human GPI2 homolog (GPI-2h) and polynucleotides which identify and encode GPI-2h. The invention also provides expression vectors, host cells, antibodies, and antagonists. The invention also provides methods for the prevention and treatment of diseases associated with expression of GPI-2h, as well as diagnostic assays.

REFERENCES:
Database EMBL/GenBank, Accession numbers R98245 and R98011, Hillier et al., submitted Sep. 1995.
Hillier, L. et al.: The WashU-Merck EST Project: Seq HS920193, Acc No R93920, yq16f11.r1 H. sapiens clone 197133 5', Sep. 1995.
Hillier, L. et al.: The WashU-Merck EST Project: Seq HS126361, Acc No W76126, zd59f05.r1 Soares fetal heart NbHH19W H. sapiens cDNA clone 344961 5', Jun. 1996.
Doering, T.L. et al., "Biosynthesis of Glycosyl Phosphatidylinositol Membrane Anchors", J. Biol. Chem., 265: 611-614 (1990).
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Watanabe, R. et al., "PIG-A and PIG-H , Which Participate in Glycosylphosphatidylinositol Anchor Biosynthesis, Form a Protein Complex in the Endoplasmic Reticulum", J. Biol. Chem., 271: 26868-26875 (1996).
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Leidich, S.D., et al., (Direct Submission), GenBank Sequence Database (Accession 841378), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 841378) (1995).
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Inoue, N. et al., "PIG-C, One of the Three Human Genes Involved in the First Step of Glycosylphosphatidylinositol Biosynthesis Is a Homologue of Saccharomyces cerevisiae GPI2", Biochem. Biophys. Res. Comm., 226: 193-199 (1996).

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