Vector for the expression of therapy-relevant genes

Details Vector for the expression of therapy-relevant genes Vector for the expression of therapy-relevant genes

1995-05-12

1999-10-19

Guzo, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 694, 435 695, 435 6951, 435 6952, 435 696, 4353201, C12Q 168, C12N 1585, C12P 2100

Patent

active

059687355

ABSTRACT:
A vector for expression of relevant therapeutic genes in mammalian cells which utilizes the mdr promoter, and optionally, the mdr enhancer, operably linked to the therapeutic gene.

REFERENCES:
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Stein, U., et al., "Point Mutations in the mdr1 Promoter of Human Osteosarcomas are Associated With In vitro Responsiveness to Multidrug Resistance Relevant Drugs", European Journal of Cancer 30A(10):1541-1545 (1994).
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Ueda, K., et al., "The Human Multidrug Resistance (mdr1) Gene", The Journal of Biological Chemistry 262(2):505-508 (1987).
Ueda, K., et al., "Isolation and Sequence of the Promoter Region of the Human Multidrug-resistance (P-glycoprotein) Gene", The Journal of Biological Chemistry 262(36):1732-17436 (1987).
Walther, W., and Stein, U., "Influence of cytokines on mdr1 expression in human colon carcinoma cell lines: increase cytotoxicity of MDR relevant drugs", J. Cancer Res. Clin. Oncol. 120:471-478 (1994).
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