Ras-binding protein (PRE1)

Details Ras-binding protein (PRE1) Ras-binding protein (PRE1)

1997-10-01

2000-10-31

Eyler, Yvonne

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 4353201, 530324, 530350, C07H 2104, C12P 2102, C12N 1500

Patent

active

061404888

ABSTRACT:
Disclosed is a Ras-binding protein designated PRE1. PRE1 occurs naturally in various mammalian tissues and cell types. An isolated DNA encoding PRE1, vectors and cells containing the DNA, and PRE1-specific antibodies are also disclosed. Also disclosed is an in vitro screening method for identifying a substance which modulates PRE1-Ras binding, and an in vitro method for identifying a substance that modulates PRE1 gene expression.

REFERENCES:
Sambrook et al. "Molecular Cloning: A Laboratory Manual" Second Ed., Cold Spring Harbor Laboratory Press, p. 11.12 to 11.13, 1989.
Current Protocols in Molecular Biology. Massachusetts General Hospital, Harvard Medical School, p. 6.4.5, 1990.
The ATCC Cell Lines and Hybridomas Catalog. 8th edition. American Type Culture Collection. p. 429, 1994.
Afar et al., "Regulation of the Oncogenic Activity of BCR-ABL by a Tightly Bound Substrate Protein R1N1", Immunity, 6:773-782, 1997.
Ahmed et al., "Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor", Biochem. J., 272:767-773, 1990.
Ahmed et al., "The Caenorhabditis elegans unc-13 gene product is a phospholipid-dependent high-affinity phorbol ester receptor", Biochem. J., 27:995-999, 1992.
Avruch et al., "Raf meets Ras: completing the framework of a signal transduction pathway", Trends in Biochem., 19:279-283, 1994.
Bos, Johannes L., "ras Oncogenes in Human Cancer: A Review", Cancer Res., 49:4682-4689, 1989.
Cahill et al., "Signalling pathways: Jack of all cascades", Cur. Biol., 6(1):16-19, 1996.
Cowley et al., "Activation of MAP Kinase Kinase Is Necessary and Sufficient for PC12 Differentiation and for Transformation of NIH 3T3 Cells", Cell, 77:841-852, 1994.
D'Arcangelo et al., "A Branched Signaling Pathway for Nerve Growth Factor Is Revealed by Src-, Ras-, and Raf-Mediated Gene Inductions", Mole. and Cell. Biol., 13:3146-3155, 1993.
Dickson et al., "Genetics of signal transduction in invertebrates", Cur. Opin. Genet. Dev., 4:67-70, 1994.
Fanti et al., "Signalling by Receptor Tyrosine Kinases", Annu. Rev. Biochem., 62:453-481, 1993.
Farrar et al., "Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization", Nature, 383:178-181, 1996.
Katz et al., "Signal transduction from multiple Ras effectors", Cur. Opin. Genet. & Dev., 7:75-79, 1997.
Khosravi-Far et al., "Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation", Mol. Cell. Biol., 15:6443-6453, 1995.
Kuroda et al., "Different Effects of Various Phospholipids on Ki-Ras-, Ha-Ras-, and Rap1B-induced B-Raf Activation", J. Biol. Chem., 271:14680-14683, 1996.
Leevers et al., Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane, Nature, 369:411-414, 1994.
Luo et al., "Oligomerization activates c-Raf-1 through a Ras-dependent mechanism", Nature, 383:181-185, 1996.
Marshall, Christopher J., "Ras effectors", Cur. Opin. Cell Biol., 8:197-204, 1996.
McCollam et al., "Functional Roles for the Pleckstrin and Dbl Homology Regions in the Ras Exchange Factor Son-of-sevenless", J. Biol. Chem., 270:15954-15957, 1995.
Mineo et al., "Physical Association with Ras Enhances Activation of Membrane-bound raf (RafCAAX)*", J. Biol. Chem., 272:10345-10348, 1996.
Mizushima et al., "pEF-BOS, a powerful mammalian expression vector", Nucl. Acids Res., 18:5322, 1990.
Oldman et al., "Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells", Proc. Natl. Acad. Sci. USA, 93:6924-6928, 1996.
Ono et al., "Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence", Proc. Natl. Acad. Sci. USA, 86:4868-4871, 1989.
Ponting et al., "A novel family of Ras-binding domains", Trends in Biochem. Sci., 21:422-425, 1996.
Qiu et al., "An essential role for Rac in Ras transformation", Nature, 374:457-459, 1995.
Ramocki et al., "Signaling through Mitogen-Activated Protein Kinase and Rac/Rho Does Not Duplicate the Effects of Activated Ras on Skeletal Myogenesis", Mol. Cell. Biol., 17:3547-3555, 1997.
Rapp et al., "raf Family Serine/Threonine Protein Kinases in Mitogen Signal Transduction", Cold Spring Harb. Symp. Quant. Biol., LIII:173-184, 1988.
Ren et al., "Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site", Science, 259:1157-1161, 1993.
Rodriguez-Viciana et al., "Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras", Cell, 89:457-467, 1997.
Sakane et al., "Porcine diacylglycerol kinase sequence has zinc finger and E-F hand motifs", Nature, 344:345-348, 1990.
Stokoe et al., "Activation of Raf as a Result of Recruitment to the Plasma Membrane", Science, 264:1463-1467, 1994.
Stokoe et al., "Activation of c-Raf-1 by Ras and Src through different mechansims: activation in vivo and in vitro", EMBO J., 16:2384-2396, 1997.
Taylor et al., "Cell cycle-dependent activation of Ras", Cur. Biol., 6(12):1621-1627, 1996.
Valencia et al., "The ras Protein Family: Evolutionary Tree and Role of Conserved Amino Acids", Biochem., 30:4637-4648, 1991.
van Corven et al., "Pertussis toxin-sensitive activation of p21.sup.ras by G protein-coupled receptor agonists in fibroblasts", Proc. Natl. Acad. Sci. USA, 90:1257-1261, 1993.
Whitehead et al., "Dbl family proteins", Biochimica et Biophysica Acta, 1332:F1-F23, 1997.
Wittinhofer et al., "How Ras-related proteins talk to their effectors", Trends in Biochem. Sci., 21:488-491, 1996.
Woodrow et al., "p21.sup.ras Function Is Important for T Cell Antigen Receptor and Protein Kinase C Regulation of Nuclear Factor of Activated T Cells", J. of Immun., 150:3853-3861, 1993.
Zhang et al., "Normal and oncogenic p21.sup.ras proteins bind to the amino-terminal regulatory domain of c-Raf-1", Nature, 364:308-313, 1993.
Zhang et al., "Kinase Suppressor of Ras Is Ceramide-aCtivated Protein Kinase", Cell, 89:63-72, 1997.
Slepnev et al., NCBI Sequence Submission, Accession No. AF002251, May 5, 1997.

Affiliated with

Also associated with

Rating

Ras-binding protein (PRE1) does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ras-binding protein (PRE1), we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ras-binding protein (PRE1) will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2053558