Small molecule inhibitors of rotamase enzyme activity

Details Small molecule inhibitors of rotamase enzyme activity Small molecule inhibitors of rotamase enzyme activity

1997-04-08

2000-10-31

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31401

Patent

active

061403571

ABSTRACT:
This invention relates to neurotrophic N-glyoxylprolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.

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