Polynucleotides encoding paraoxonase

Details Polynucleotides encoding paraoxonase Polynucleotides encoding paraoxonase

1998-04-27

2000-10-31

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435325, 4353201, 4352523, 435348, 435365, 435358, 435419, 514 44, 536 232, 536 231, C12N 916

Patent

active

061400939

ABSTRACT:
Human paraoxonase enzyme and DNA (RNA) encoding such paraoxonase enzymes are disclosed. Also provided is the procedure for producing such polypeptides by recombinant techniques. Uses of such polypeptides include their use as an antidote for organophosphate poisoning and to prevent neuronal cell death.

REFERENCES:
S. Adkins, et al., "Molecular Basis for the Polymorphic forms of Human Serum Paraoxonase/Arylesterase: Glutamine or Arginie at Position 191, for the Respective A or B allozymes," American Journal of Human Genetics, 52:598-608 (1993).
C.E. Furlong, et al., "Human and Rabbit Paraoxonases: Purification, Cloning, Sequencing, Mapping and Role of Polymorphism in Organophosphorus Detoxification," Chem.-Biol. Interactions. 87:35-48 (1993).
Hasset et al. (1991) Biochemistry 30(42):10141-10149.
La Du et al. (1987) Chem. Biol. Interactions 87:25-34.
Shaw et al. (1994) Biochem. J. 298(3):675-680.
Adkins et al. (1993) FASEB J. 7(4):A803.
Smolen A. et al., Drug Metabolism and Disposition, vol. 19:107-112 (1991).
Humbert, R. et al., Nature Genetics, vol. 3:73-76 (1993).

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