TNF receptor death ligand proteins and inhibitors of ligand bind

Details TNF receptor death ligand proteins and inhibitors of ligand bind TNF receptor death ligand proteins and inhibitors of ligand bind

1995-09-26

1998-12-22

Walsh, Stephen

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

514 2, 514 12, 435 691, 435325, 530300, 530351, C07K 1747, C07K 1452, C12N 1510

Patent

active

058521739

ABSTRACT:
Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.

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