ATP-dependent RNA helicase protein

Details ATP-dependent RNA helicase protein ATP-dependent RNA helicase protein

1998-09-09

2000-10-31

Slobodyansky, Elizabeth

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

424 946, 435183, 435195, 530324, 530325, 530326, A61K 3843, A61K 3846, A61K 3810, C12N 900, C12N 914

Patent

active

061398373

ABSTRACT:
The invention provides a human ATP-dependent RNA helicase (ADRH-1) and polynucleotides which identify and encode ADRH-1. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of ADRH-1.

REFERENCES:
Murphy et al. (Jul. 19, 1996) GenBank Accession S67386.
Ripmaster, T.L., et al., "A putative ATP-dependent RNA helicase involved in Saccharomyces cerevisiae ribosome assembly", Proc. Natl. Acad. Sci. USA, 89:11131-11135 (1992).
Chang, T., et al., "Identification of five putative yeast RNA helicase genes", Proc. Natl. Acad. Sci. USA, 87:1571-1575 (1990).
Pause, A., et al., "The HRIGRXXR Region of the DEAD Box RNA Helicase Eukaryotic Translation Initiation Factor 4A Is Required for RNA Binding and ATP Hydrolysis", Molecular and Cellular Biology, 13:6789-6798 (1993).
Drysdale, B., et al., (Nov. 01, 1996) GenBank Sequence Database (Accession Q51119), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849. (GI 1335873).
Wilson, R., et al., "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans", Nature, 368:32-38 (1994).
Wilson, R., et al., (GI 17077045) GenBank Sequence Database (Accession U80447), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849. (GI 1707046).
Zhang, S, et al., "Nuclear DNA Helicase II Unwinds both DNA and RNA", Biochemistry, 33:3906-3912 (1994).

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