Heteroatom substituted benzoyl derivatives that enhance synaptic

Details Heteroatom substituted benzoyl derivatives that enhance synaptic Heteroatom substituted benzoyl derivatives that enhance synaptic

Filed on

1995-06-05

Date issued

1998-12-22

Examiner

Gupta, Yogendra N.

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Heterocyclic carbon compounds containing a hetero ring...

Other Related Categories

514321, 514422, 540607, 546197, 548526, A61K 3155, C07D40310

Type

Patent

Status

active

Patent number

058520082

Description

ABSTRACT:
Compounds having the following structural formula, ##STR1## are useful for enhancing synaptic response mediated by AMPA receptors are disclosed, the invention compounds can also be used for the treatment of non-impaired subject for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptor and for improving memory encoding.

REFERENCES:
patent: 2456991 (1948-12-01), Prill
patent: 2487179 (1949-11-01), Prill
patent: 2773062 (1956-12-01), Prill
patent: 3869431 (1975-03-01), Spiewak
patent: 3982001 (1976-09-01), Heffe et al.
patent: 4025629 (1977-05-01), Coverdale
patent: 4117228 (1978-09-01), Tanaka et al.
patent: 4209445 (1980-06-01), Oediger et al.
patent: 4209446 (1980-06-01), Schulze et al.
patent: 4209517 (1980-06-01), Riveron et al.
patent: 4333938 (1982-06-01), Creuzet et al.
patent: 4369139 (1983-01-01), Kyburz et al.
patent: 4425327 (1984-01-01), Moller et al.
patent: 4431662 (1984-02-01), Hodgson, Jr.
patent: 4438142 (1984-03-01), Vinegar
patent: 4452807 (1984-06-01), Aschwanden et al.
patent: 4499100 (1985-02-01), Kluge et al.
patent: 4535159 (1985-08-01), Forne et al.
patent: 4543361 (1985-09-01), Muchowski et al.
patent: 4548949 (1985-10-01), Muchowski et al.
patent: 4937360 (1990-06-01), Liu et al.
patent: 4948804 (1990-08-01), Galliani et al.
patent: 5196439 (1993-03-01), Sugimoto et al.
patent: 5324839 (1994-06-01), Clemence et al.
Journal of Physiology, 424, pp. 533-543, 1990.
CA 104:10668d, 1986.
Chemical Abstracts, vol. 104, No. 2, 1986, Columbus, Ohio, US; Abstract No. 10668d, p. 324; col. 2.
Chemical Abstracts, vol. 88, No. 23, 1978, Columbus, Ohio, US; Abstract No. 169713n, p. 552; col. 2.
Chemical Abstracts, vol. 58, No. 38, 1963, Columbus, Ohio, US; Abstract No. 4541d, col. 4541.
Abdulla, Riaz F., J. Heter. Chem., 10(3):347-351 (1973).
Abou-Ouf, A.A., et al., Egypt. J. Pharm. Sci., 13(I):187-194 (1972).
Baudry, D., et al., Tetrahedron Letters, 54:4707-4710 (1970).
Baudry, D., et al., Bulletin de la Societe Chimque de France, 4:1413-1415 (1971) w/English abstract, see Chemical Abstracts, 75:300 No. 48308g (1971).
Cacchi, S., et al., Tetrahedron Letters, 27(33):3931-3934 (1986).
Gourdie, T.A., et al., J. Med. Chem., 33:1177-1186 (1990).
Housny, A., et al., Polymer Prepr., 27(1):120-121 (1986).
Ritter, D., et al., Chem. Ber., 119:3704-3717 (1986).
Sam. Joseph, et al., J. Pharm. Sci., 56(6):729-731 (1967).
Schwarz, G., et al., Liebigs Ann. Chem., 1257-1270 (1981).
Tilly, G., Chimie Therapeutique, 1:57-65 (1967).

Affiliated with

Also associated with

Rating

Heteroatom substituted benzoyl derivatives that enhance synaptic does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heteroatom substituted benzoyl derivatives that enhance synaptic, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heteroatom substituted benzoyl derivatives that enhance synaptic will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2047836