Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1991-08-12
1992-11-03
Pellegrino, Stephen C.
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
604 80, 604 82, A61M 3700
Patent
active
051603209
DESCRIPTION:
DESCRIPTION
MODES FOR CARRYING OUT THE INVENTION
FIG. 1 illustrates an operative intravenous delivery system, generally designated by the numeral 10, showing the positioning of an agent formulator 30 therein. System 10 comprises a container 12 that contains a fluid 13 suitable for intravenous administration, and an administration set, generally designated 14. The fluid 13 in container 12 will typically be a medical fluid, i.e., a sterile solution such as an aqueous solution of dextrose, saline, and/or electrolytes. Fluid 13 is a vehicle for intravenous administration of a pharmaceutical agent to a recipient. Container 12 is manufactured from glass or plastic, and is preferably of the no air-tube vacuum type and thus it is used with an administration set that has an air inlet filter. Other types of containers such as the air-tube vacuum type, or the non-vented type, can be used for the intended purpose. These alternative containers do not require an air filter in the administration set. Container 12 can be rigid, semi-rigid or flexible in structure, and it is usually adapted to be hung neck-down from a hanger 15 by a handle 16 that connects or surrounds container 12. The neck of container 12 is covered by a closure 17, generally made of rubber and air-tight.
Alternatively, container 12 can take the form of an infusor or a syringe pump (not shown in the Figures), and in particular a portable infusor or syringe pump, of the kind known in this art.
Administration set 14 and container 12 are interconnected by piercing closure 17 with one end of a hollow spike 18 attached to or formed as a part of administration set 14. Spike 18 is equipped with a side air vent 19. The other end of spike 18 is enlarged and fits snugly into a drip chamber 22. Drip chamber 22 traps air contained in the set 14 and facilitates adjusting the flow rate of intravenous fluid 13 from container 12 as the flow proceeds drop wise. The outlet at the bottom of drip chamber 22 is connected to a first segment of tubing 23 which fits into agent formulator 30, the details of which are presented in FIGS. 2 and 3. A second segment of tubing 25 leads from agent formulator 30 to bacterial filter 27. A third segment of tubing 29 extends from filter 27 to an infusion agent receptor site, terminating in an adapter-needle assembly 28 that is inserted into a vein of a warm-blooded animal 20, shown as a human arm. A piece of tape 21 holds adapter-needle assembly 28 firmly in place on the recipient's arm. The administration set can also include a pair of tubing clamps 24 and 26 located on either side of formulator 30 which may be used to govern or stop the flow of intravenous fluid through the intravenous delivery system 10.
In one embodiment of the present invention, a portion of the wall of container 12 is comprised of a material 11 which is permeable to the beneficial agent contained within, and delivered by, the delivery device 40. The wall portion 11 forms a "drug delivery window" within the otherwise impermeable wall of container 12. During delivery of beneficial agent from device 40, the IV fluid 13 must be in contact with the interior surface of wall portion 11. Accordingly, the wall portion 11 is preferably located in a downstream portion of the wall of container 12 most preferably adjacent the neck of container 12.
As an alternative to, or in addition to the drug delivery window 11 in container 12, an agent formulator 30 may be provided downstream from the container 12. Agent formulator 30, as seen in FIGS. 2 and 3, comprises a wall 32 forming a chamber 34. At least a portion of the wall 32 is comprised of a material 36 which is permeable to the beneficial agent contained within, and delivered by, the delivery device 40. The wall portion 36 forms a drug delivery window, similar to wall portion 11, within the otherwise impermeable wall 32 which may be formed of glass, plastic or the like.
As best shown in FIGS. 2 and 3, a flow diverter 38 is provided within chamber 34. The flow diverter 38 is secured within chamber 34 by supports 39. Preferably, formulator 30
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Theeuwes Felix
Yum Su I.
ALZA Corporation
Mandell Edward L.
Miller D. Byron
Pellegrino Stephen C.
Rafa Michael
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