Transcriptional promoter of the murine obesity gene

Details Transcriptional promoter of the murine obesity gene Transcriptional promoter of the murine obesity gene

1995-11-16

1997-12-16

Elliott, George C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435325, 536 231, 536 241, C12N 510, C12N 1511, C12Q 100

Patent

active

056983891

ABSTRACT:
The invention relates to the Ob gene transcriptional promoter. The subject promoters generally comprise a C/EBP binding site and a novel untranslated Ob gene exon. Ob gene promoters are used in diagnosis and pharmaceutical development. In particular, transfected adipocytes comprising Ob gene promoters operably linked to a reporter are used in high-throughput pharmaceutical screens.

REFERENCES:
He et al., The Journal of Biological Chemistry 270(48):28887-28891 (1995).
Miller et al., Proc. Natl. Acad. Sci. USA 93(11):5507-5511 (1996).
Zhang et al., Nature 372:425-432 (1994).

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