Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus esters
Patent
1995-04-14
1996-05-21
Richter, Johann
Organic compounds -- part of the class 532-570 series
Organic compounds
Phosphorus esters
558146, C07F 910
Patent
active
055191592
DESCRIPTION:
BRIEF SUMMARY
This application is a national stage filing under 35 U.S.C. .sctn. 371 that is based upon PCT International Application No. PCT/JP93/01462, which was filed on Oct. 12, 1993.
TECHNICAL FIELD
The present invention relates to a phosphatidylcholine excellent in oxidation stability, and a process for producing the same.
BACKGROUND ART
In general, phosphatidylcholines contain as a constituent fatty acid thereof an unsaturated fatty acid such as oleic acid, linoleic acid, linolenic acid, docosahexaenic acid or arachidonic acid, so that they have the property of being readily oxidized. In particular, when phosphatidylcholines are purified to high purity, they are separated from neutral lipids or proteins which have existed as impurities and acted just like protective layers, and directly exposed to oxygen in the air, so that they are oxidized more easily.
For this reason, there has been made an effort to prevent phosphatidylcholines from being oxidized, e.g., during storage. Generally, they are stored in a dark and cool place or in an inert gas atmosphere; an antioxidant such as vitamin E is added to them; or an unsaturated bond contained in them is converted into a saturated bond by hydrogenation.
Phosphatidylcholines which are purified to high purity are often used for cosmetics, drugs or the like. In such cases, they are usually utilized as liposomes, emulsifying agents or the like. It has been known that, in such cases, the smaller is the amount of impurities such as inorganic salts and free amino acids, the better are the products obtained. (See, for example, Japanese Laid-Open Patent Publication No. 3115/1989.)
However, although storage in a dark and cool place or in an inert gas atmosphere is effective for phosphatidylcholines prepared, it is impractical and almost impossible for those products such as cosmetics and drugs which are produced by using the phosphatidylcholines.
Further, the addition of an antioxidant to phosphatidylcholines is unfavorable when their use in cosmetics, drugs, foods or the like is taken into consideration. There is also a case where an antioxidant cannot be added.
Furthermore, in order to conduct a hydrogenation treatment, it is necessary to additionally provide a step for this purpose.
In addition, the stability of liposomes or emulsified products obtained by using phosphatidylcholines is reduced when the phosphatidylcholines are oxidized. Moreover, the phosphatidylcholine oxides also bring about the problem of toxicity for the body or the like.
It has thus been general rules that purified phosphatidylcholines should be stored in a dark and cool place immediately after the preparation thereof and used for producing desired products as soon as possible, and that the products obtained should also be consumed in a short period of time.
Under these circumstances, it is now acknowledged that the development of phosphatidylcholines which are per se excellent in oxidation stability is strongly required.
Therefore, an object of the present invention is to provide phosphatidylcholines excellent in oxidation stability and thus can meet the above requirement.
SUMMARY OF THE INVENTION
We have made extensive studies in order to attain the aforementioned object, and finally accomplished the present invention.
The present invention is to provide a phosphatidylcholine characterized in that the ratio of the total weight of palmitoyl-linoleoyl-glycerophosphocholine (PLPC) and palmitoyl-oleoyl-glycerophosphocholine (POPC) to the total weight of stearoyl-linoleoyl-glycerophosphocholine (SLPC) and stearoyl-oleoyl-glycerophosphocholine (SOPC) is 4.5 or less, the PLPC, POPC, SLPC and SOPC being molecular species constituting the phosphatidylcholine, and that the electric conductivity of a 5 wt. % suspension of the phosphatidylcholine in distilled water is 100 .mu.S/cm or less.
BRIEF DESCRIPTION OF THE DRAWING
FIG. 1 is a graph showing the ultraviolet absorption chromatogram of the eluate obtained in Example 1 of the present invention.
BEST MODE FOR CARRYING OUT THE INVENTION
The phospha
REFERENCES:
patent: 4857236 (1989-08-01), Gunther
patent: 4983327 (1991-01-01), Gunther
Hasegawa Mineo
Kobayashi Hideaki
Narabe Hitoshi
Ambrose Michael G.
Kewpie Kabushiki Kaisha
Richter Johann
LandOfFree
Phosphatidylcholine with high oxidative stability and process fo does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Phosphatidylcholine with high oxidative stability and process fo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phosphatidylcholine with high oxidative stability and process fo will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2039235