Chelating agents, their preparation from the antibiotics salmyci

Details Chelating agents, their preparation from the antibiotics salmyci Chelating agents, their preparation from the antibiotics salmyci

1994-08-05

1996-05-21

Nutter, Nathan M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1304, A61K 3170

Patent

active

055191231

ABSTRACT:
The novel substances nordanoxamine and desferrinordanoxamine, and desferrisalmycin A, B, C and D, as well as the known substances danoxamine and desferridanoxamine, are prepared from the antibiotics salmycin A, B, C and D, which are obtained by fermentation. These substances are used as chelating agents and pharmaceuticals.

REFERENCES:
Bergeron et al., "The Total Synthesis of Desferrioxamines E and G," Tetrahedron, 46, 5881-5888 (1990).
"Stoffwechselprodukte von Mikroorganismen", P. Huber et. al., Helvetica Chimica Acta, 69:236-245 (1986).
"Sysnthesis of the Metabolite--Hydroxy-Desferrioxamine B", Barbara Roggo et. al., The Journal of Antibiotics, 46(2):294-299 (Feb. 1993).

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