Lysosphingolipid derivatives

Details Lysosphingolipid derivatives Lysosphingolipid derivatives

1992-07-21

1996-05-21

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 53, 514114, 514564, 536 179, 536120, 558169, 558175, 562564, C07H 1100, C07H 1504, A61K 3170, C07F 902

Patent

active

055190073

ABSTRACT:
Novel derivatives of lysophingolipids free from sialic acids which are N-acyllysosphingolipids having one of the two formulae: ##STR1## in which --A-- stands for the group --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --, n.sub.1 is a whole number of between 6 and 18, n.sub.2 is a whole number of between 11 and 15, X is a hydrogen atom or the residue of a monosaccharide or a disaccharide or phosphorylcholine and R represents an alkyl radical derived from a saturated or unsaturated aliphatic carboxylic acid having from 2 to 24 carbon atoms substituted by one or more polar groups. The lysosphingolipid derivatives of the invention exhibit an inhibiting action on protein-kinase C activation and, thus, can be utilized in therapies for various pathologies of the nervous system.

REFERENCES:
patent: 4937328 (1990-06-01), Schmidt et al.
patent: 4952683 (1990-08-01), Tschannen et al.
Neuro Report, vol. 3, issued 1992, Lipartit et al, "Ganglioside Derivative LIGA20 Reduces NMDA Neurotoxicity in Neonatal Rat Brain", pp. 919-921.
The Journal of Pharmacology and Experimental Therapeutics, vol. 268, No. 1, issued 1994, Seren et al, "Orally Administered Glycolipid Derivative LIGA20 Reduces Infarct Volume and Behavioral Impairment after Focal Cerebral Ischemia", pp. 460-465.
The American Society for Pharmacology and Experimental Therapeutics, vol. 252, No. 1, issued 1989, Manev et al, "Glutamate-Induced Neuronal Death in Primary Cultures of Cerebellar Granule Cells: Protection by Synthetic Derivatives of Endogenous Sphingolipids," pp. 419-427.
M. A. Findeis et al Journal of Organic Chemistry, vol. 52 (1987) pp. 2838-2848.
M. Kiso et al Carbohydrate Research, vol. 158 (1986) pp. 101-111.
A. E. Gal et al Chemistry and Physics of Lipids, vol. 42 (1986) pp. 199-207.
F. Vaccarino et al Proc. Natl. Acad. Sci. USA, vol. 84 (1987) pp. 8706-8711.
Y. A. Hannun et al Journal of Biological Chemistry, vol. 261 No. 27 (1986) pp. 12604-12609.
A. H. Merril, Jr. et al Journal of Biological Chemistry, vol. 261, No. 27 (1986) pp. 12610-12615.
E. Wilson et al Journal of Biological Chemistry, vol. 261, No. 27 (1986) pp. 12616-12623.
Y. A. Hannun et al Science, vol. 235, pp. 670-673 (1986).
V. Gallo et al Proc. Natl. Acad. Sci. USA, vol. 79 (1982) pp. 7919-7923.
F. M. Vaccarino et al The Journal of Neuroscience, vol. 7, No. 1 (1987) pp. 65-76.
T. Yoshino et al Biochemistry, vol. 21 (1982) pp. 928-934.
D. Shapiro et al. Journal of Organic Chemistry, vol. 28 (1963) pp. 2157-2160.
B. Weiss et al Journal of Organic Chemistry, vol. 35, No. 10 (1970) pp. 3543-3546.
R. C. Arora et al Archives of Biochemistry and Biophysics, vol. 156 (1973) pp. 77-83.
G. A. Grabowski et al Analytical Biochemistry, vol. 141 (1984) pp. 276-279.
K. R. Warren et al Journal of Neurochemistry, vol. 26 (1976) pp. 1063-1072.
R. A. Pagano et al Biochemistry, vol. 27 (1988) pp. 4439-4445.
D. Shapiro et al Journal of the American Chemical Society, vol. 86, No. 20 (1964) pp. 4472-4476.
B. Weiss et al Journal of Chemical and Engineering Data, vol. 13, No. 3 (1986) pp. 450-451.
R. J. Turel et al CA 94:83548z (Dept. of Chemistry, Univ. Bombay, India), issued 16 Mar. 1981.
I. Pascher Chemistry and Physics of Lipids, vol. 12 (1974) pp. 303-315.
H. Sugimoto et al CA 112:56573n (Shionogi and Co., Ltd.), issued 12 Feb. 1990.
J. B. Hay et al Chem. Phys. Lipids, vol. 3 (1969) pp. 59-69
T. Umemura et al Agric. Biol. Chem., vol. 51, No. 7 (1987) pp. 1973-1982.
H. Manev et al Journal of Pharmacol. Exp. Ther., vol. 252, No. 1 (1990) pp. 419-427.

Affiliated with

Also associated with

Rating

Lysosphingolipid derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Lysosphingolipid derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lysosphingolipid derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2038133