Preparation of human myelomonocyte interferon-gamma

Details Preparation of human myelomonocyte interferon-gamma Preparation of human myelomonocyte interferon-gamma

1994-11-07

1996-05-21

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

424 855, 4352402, 530351, C12P 2102, A61K 3766, C07K 700

Patent

active

055188990

ABSTRACT:
The present invention relates to a novel human interferon-gamma derived from an established human myelomonocyte, a process to prepare said interferon-gamma, and its use. The human myelomonocyte interferon-gamma has a novel polypeptide and carbohydrate chain structure, and it is effective in preventing and treating viral diseases, malignant tumors and immunopathies alone or in combination with other lymphokine and/or chemotherapeutic. The human myelomonocyte interferon-gamma may be produced by culturing an established human myelomonocyte on a culture medium in vitro. Alternatively, an established human myelomonocyte is implanted in a non-human warm-blooded animal or in a diffusion chamber placed inside or outside the body of the animal, and then allowed to proliferate while receiving nutrient body fluid from the animal. The human myelomonocyte may be contacted with an inducer during propagation.

REFERENCES:
patent: 4791101 (1988-12-01), Adolf
patent: 4946674 (1990-08-01), von Eichborn et al.
Miyata et al. (1986) J. Biochem. 99 1681-1688.
Braude (1984) Biochemistry 23 5603-5609.
Gray et al (1982) Nature 295:503-508.
Devos et al. (1984) J. Interferan Res. 4 461-468.
Yamamoto et al., Studies on the Sugar Chains of Interferon from Human Peripheral-Blood Lymphocytes, J. Biochem.105:1034-1039 (1989).

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